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Gary Felsenfeld
Gary Felsenfeld received his training in physical biochemistry as an undergraduate with John Edsall at Harvard, his doctoral training in chemical quantum mechanics with Linus Pauling at CalTech. Most of
his career has been spent at the National Institutes of Health.
His early work (with D.R. Davies and A. Rich) focused on the formation in solution of ordered two-and three-stranded polynucleotide structures. This led to an interest in the role of electrostatic forces and ionic interactions in stabilization of these structures, and finally to the study of nucleic acid-protein
interactions, particularly the structure and function of chromatin, the DNA-protein complex that organizes the genetic material in eukaryotic nuclei. |
At first he addressed questions of nucleosome
structure and stability, and gradually this led to an interest in the relationship between chromatin structure and gene expression, with a focus on the chicken beta-globin locus as a test system.
Following identification of erythroid-specific regulatory factors such as GATA-1, he extended his studies to the larger chromatin domain in which these genes are embedded. This in turn led to the discovery of the compound insulator elements that surround the beta globin locus, and to the identification of CTCF as a boundary factor that plays an important role in regulation of imprinted loci and large scale genome organization. Present interests include the identification and characterization of boundary elements and
their effect on chromatin conformation and function within the nucleus, the role of histone variants in genome organization and gene expression, and the physical and biochemical properties of constitutively condensed chromatin in vertebrates. |
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INVITED SPEAKERS |
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Werner Arber (University of
Basel) |
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Giorgio Bernardi (Stazione
Zoologica Anton Dohrn, Napoli) |
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John Buckeridge (RMIT University, Melbourne, Australia) |
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Luca Cavalli-Sforza (Stanford University) |
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Bryan Clarke (School of Biology
University Park, Nottingham) |
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Rita Colwell (University
of Maryland, College Park) |
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Eric Davidson |
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Christian De Duve (Christian
de Duve Institute of Cellular Pathology, Bruxelles) |
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Marcus Feldman (Department of Biology, Stanford University) |
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Gary Felsenfeld |
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Walter Gehring (Growth & Development, Biozentrum, University of Basel) |
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Takashi Gojobori (National
Institute of Genetics, Mishima) |
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Daniel Hartl (Harvard University,
Cambridge) |
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Nicole Le Douarin (Collège de France, Académie des Sciences) |
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Gabriel Macaya (Centro de investigacion en biologia
cellular y molecular, Universidad de Costa Rica) |
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William Martin (Institut für Botanik III, Heinrich Heine-Universität, Düsseldorf) |
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Gerd Müller (Department of Theoretical Biology,
University of Vienna) |
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Werner E.G. Müller (Institut für Physiologische Chemie, Abteilung Angewandte
Molekularbiologie, Universität Mainz) |
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Tomoko Ohta (National Institute of Genetics) |
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Norihiro Okada (Tokyo Institute of Technology, Yokohama) |
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Nori Satoh (Department of Zoology, Division of Biological Science, Graduate
School of Science, Kyoto University) |
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Maxine Singer (Carnegie Institution of Washington) |
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Vittorio Sgaramella (Parco
Tecnologico Padano - CERSA, Lodi) |
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Marc Van Montagu (European Federation of Biotechnology) |
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Marvalee Wake (University of
California, Berkeley) |
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James Watson |
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Emile Zuckerkandl (Institute
of Molecular Medical Sciences, Palo Alto) |
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©
Istituto Veneto di Scienze, Lettere ed Arti |
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