Pierluigi Nicotera
Direttore Scientifico e CEO del DAZNE - Centro Nazionale delle Malattie Neurodegenerative in Germania

- s.s. eletto il 27 giugno 2023

Publications

23.01.2023
Scopus
1. A, Wang Y, Jackson J, Wischhof L, Zeisler-Diehl V, Scifo E, et al. CEST-2.2 overexpression Scuteri D, Guida F, Boccella S, Luongo L, Maione S, Tonin P, et al. NAbiximols Clinical Translation To the treatment of Pain and Agitation In Severe Dementia (NACTOPAISD): Clinical trial protocol. Biomedicine and Pharmacotherapy 2022, 153. 
2. Scuteri D, Tonin P, Nicotera P, Vulnera M, Altieri GC, Tarsitano A, et al. Pooled Analysis of Real-World Evidence Supports Anti-CGRP mAbs and Onabotulinumtoxin: A Combined Trial in Chronic Migraine. Toxins 2022, 14(8).
3. Scuteri D, Bagetta G, Nicotera P. Dementia therapeutics and cognitive rehabilitation. Current Opinion in Pharmacology, 65.   
4. Jackson J, Wischhof L, Scifo E, Pellizzer A, Wang Y, Piazzesi A, et al. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Molecular Metabolism 2022, 61.
5. Scuteri D, Contrada M, Loria T, Sturino D, Cerasa A, Tonin P, et al. Pain and agitation treatment in severe dementia patients: The need for Italian Mobilization-Observation-Behavior-Intensity-Dementia (I-MOBID2) pain scale translation, adaptation and validation with psychometric testing. Biomedicine and Pharmacotherapy 2022, 150.
6. Piazzesi alters lipid metabolism and extends longevity of mitochondrial mutants. EMBO Reports 2022, 23 (5).
7. Scuteri D, Contrada M, Loria,T, Tonin P, Sandrini G, Tamburin S, Nicotera,P. et al. Pharmacological Treatment of Pain and Agitation in Severe Dementia and Responsiveness to Change of the Italian Mobilization-Observation-Behavior-Intensity-Dementia (I-MOBID2) Pain Scale: Study Protocol. Brain Sciences 2022, 12(5).
8. Wischhof L, Adhikari A, Mondal M, Marsal-Cots A, Biernat J. Mandelkow EM, et al. Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau. Journal of Biological Chemistry 2022, 298(4).    
9. Schultze JL, Gabriel M, Nicotera, P. Time for a voluntary crisis research service. Cell Death and Differentiation 2022, 29 (4), pp. 888-890. 
10. Scuteri D, Sakurada S, Sakurada T, Tonin P, Bagetta G, Nicotera P. et al. Requirements for Translation in Clinical Trials of Aromatherapy: The Case of the Essential Oil of Bergamot (BEO) for Management of Agitation in Severe Dementia. Current Pharmaceutical Design 2022, 28 (20), pp. 1607-1610. 
11. Scuteri, D, Tonin P. Nicotera P, Bagetta G, Corasaniti,MT. Real world considerations for newly approved CGRP receptor antagonists in migraine care. Expert Review of Neurotherapeutics, 22 (3), pp. 221-230. 
12. Scuteri D, Rombolà L, Tonin P, Sandrini G, Corasaniti MT, Nicotera P, et al. Genetic variants of CGRP signaling pathway in migraine: impact on novel therapeutics. Confinia Cephalalgica 2022, 31 (3). 
13. Pignolo L, Tonin P, Nicotera P, Bagetta G, Scuteri D. ROBOCOP (ROBOtic Care of Poststroke Pain): Study Protocol for a Randomized Trial to Assess Robot-Assisted Functional and Motor Recovery and Impact on Poststroke Pain Development. Front Neurol 2022;13. 
14. Scuteri D, Contrada M, Tonin P, Corasaniti MT, Nicotera P, Bagetta G. Dementia and COVID-19: A Case Report and Literature Review on Pain Management. Pharmaceuticals 2022;15(2). 
15. Wischhof L, Lee HM, Tutas,J, Overkott C, Tedt E, Stork M, et al. BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation. EMBO Journal 2021, 41 (23).
16. Scuteri D, Corasaniti MT, Tonin P, Nicotera P, Bagetta G. New trends in pharmacological control of neuropsychiatric symptoms of dementia. Curr Opin Pharmacol 2021;61:69-76. 
17. Scuteri D, Corasaniti MT, Tonin P, Nicotera P, Bagetta G. Role of CGRP pathway polymorphisms in migraine: a systematic review and impact on CGRP mAbs migraine therapy. J Headache Pain 2021;22(1). 
18. Scuteri D, Sandrini G, Tamburin S, Corasaniti MT, Nicotera P, Tonin P, et al. Bergamot rehabilitation AgaINst agitation in dementia (BRAINAID): Study protocol for a randomized, double-blind, placebo-controlled trial to assess the efficacy of furocoumarin-free bergamot loaded in a nanotechnology-based delivery system of the essential oil in the treatment of agitation in elderly affected by severe dementia. Phytother Res 2021;35(10):5333-5338. 
19. Bano D, Salomoni P, Ehninger D, Nicotera P. The histone code in dementia: Transcriptional and chromatin plasticity fades away. Curr Opin Pharmacol 2021;60:117-122. 
20. Ermer V, Nicotera P, Stainbrook SC. Cell death: Cell death by apoptosis and necrosis. Encyclopedia of Biological Chemistry: Third Edition; 2021. p. 38-41. 
21. Bertan F, Wischhof L, Scifo E, Guranda M, Jackson J, Marsal-Cots A, et al. Comparative analysis of CI- and CIV-containing respiratory supercomplexes at single-cell resolution. Cell Rep Method 2021;1(1). 
22. Scuteri D, Cassano R, Trombino S, Russo R, Mizoguchi H, Watanabe C, et al. Development and translation of nanobeo, a nanotechnology-based delivery system of bergamot essential oil deprived of furocumarins, in the control of agitation in severe dementia. Pharmaceutics 2021;13(3). 
23. Bertan F, Wischhof L, Sosulina L, Mittag M, Dalügge D, Fornarelli A, et al. Correction: Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability (Cell Death & Differentiation, (2020), 27, 12, (3354-3373), 10.1038/s41418-020-0584-2). Cell Death Differ 2021;28(3):1134. 
24. Zhivotovsky B, Nicotera P. On Sten Orrenius (1937-2020). Cell Death Differ 2020;27(9):2744-2745. 
25. Bertan F, Wischhof L, Sosulina L, Mittag M, Dalügge D, Fornarelli A, et al. Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability. Cell Death Differ 2020. 
26. Cavaliere F, Fornarelli A, Bertan F, Russo R, Marsal-Cots A, Morrone LA, et al. The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux. Sci Rep 2019;9(1). 
27. Gioran A, Piazzesi A, Bertan F, Schroer J, Wischhof L, Nicotera P, et al. Multi-omics identify xanthine as a pro-survival metabolite for nematodes with mitochondrial dysfunction. EMBO J 2019;38(6). 
28. Troulinaki K, Büttner S, Marsal Cots A, Maida S, Meyer K, Bertan F, et al. WAH-1/AIF regulates mitochondrial oxidative phosphorylation in the nematode Caenorhabditis elegans. Cell Death Discov 2018;4(1). 
29. Wischhof L, Gioran A, Sonntag-Bensch D, Piazzesi A, Stork M, Nicotera P, et al. A disease-associated Aifm1 variant induces severe myopathy in knockin mice. Mol Metab 2018;13:10-23. 
30. Sellin J, Wingen C, Gosejacob D, Senyilmaz D, Hänschke L, Büttner S, et al. Dietary rescue of lipotoxicity-induced mitochondrial damage in Peroxin19 mutants. PloS Biol 2018;16(6). 
31. Wischhof L, Maida S, Piazzesi A, Gioran A, Barragan Sanz K, Irsen S, et al. The SWI/SNF subunit Bcl7a contributes to motor coordination and Purkinje cell function. Sci Rep 2017;7(1). 
32. Amodeo V, Deli A, Betts J, Bartesaghi S, Zhang Y, Richard-Londt A, et al. A PML/Slit Axis Controls Physiological Cell Migration and Cancer Invasion in the CNS. Cell Rep 2017;20(2):411-426. 
33. Bano D, Jewell SA, Nicotera P. Calcium signaling then and now, via Stockholm. Biochem Biophys Res Commun 2017;482(3):384-387. 
34. Bano D, Piazzesi A, Salomoni P, Nicotera P. The histone variant H3.3 claims its place in the crowded scene of epigenetics. Aging 2017;9(3):602-614. 
35. Piazzesi A, Papić D, Bertan F, Salomoni P, Nicotera P, Bano D. Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs. Cell Rep 2016;17(4):987-996. 
36. Niklison-Chirou MV, Killick R, Knight RA, Nicotera P, Melino G, Agostini M. How Does p73 Cause Neuronal Defects? Mol Neurobiol 2016;53(7):4509-4520. 
37. Heneka MT, Nicotera P. Thoughts on Obesity and Brain Glucose. Cell 2016;165(4):773-775. 
38. Meyer K, Buettner S, Ghezzi D, Zeviani M, Bano D, Nicotera P. Loss of apoptosis-inducing factor critically affects MIA40 function. Cell Death Dis 2015;6(7). 
39. Bartesaghi S, Graziano V, Galavotti S, Henriquez NV, Betts J, Saxena J, et al. Erratum: Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells (Proc Natl Acad Sci USA (2015) 112 (1059-1064) DOI: 10.1073/pnas.1413165112). Proc Natl Acad Sci U S A 2015;112(11):E1401. 
40. Schmöle A-, Lundt R, Ternes S, Albayram T, Ulas T, Schultze JL, et al. Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer's disease mouse model. Neurobiol Aging 2015;36(2):710-719. 
41. Bartesaghi S, Graziano V, Galavotti S, Henriquez NV, Betts J, Saxena J, et al. Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells. Proc Natl Acad Sci U S A 2015;112(4):1059-1064. 
42. Jakubik M, Floriddia EM, Nicotera P, Bano D. Heterozygous Igf1r deletion does not ameliorate pathological features associated with polyglutamine-containing huntingtin fragment. Neurosci Lett 2014;580:52-55. 
43. Tufi R, Gandhi S, De Castro IP, Lehmann S, Angelova PR, Dinsdale D, et al. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nature Cell Biol 2014;16(2):157-166. 
44. Gioran A, Nicotera P, Bano D. Impaired mitochondrial respiration promotes dendritic branching via the AMPK signaling pathway. Cell Death Dis 2014;5(4). 
45. Piyanova A, Albayram O, Rossi CA, Farwanah H, Michel K, Nicotera P, et al. Loss of CB1 receptors leads to decreased cathepsin D levels and accelerated lipofuscin accumulation in the hippocampus. Mech Ageing Dev 2013;134(9):391-399. 
46. Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M, et al. Erratum: Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells (Journal of Clinical Investigation (2009) 119:5 (1109-1123) DOI: 10.1172/JCI35660). J Clin Invest 2013;123(8):3634. 
47. Ermer V, Nicotera P. Cell Death by Apoptosis and Necrosis. Encyclopedia of Biological Chemistry: Second Edition; 2013. p. 423-425. 
48. Dimmeler S, Nicotera P. MicroRNAs in age-related diseases. EMBO Mol Med 2013;5(2):180-190. 
49. Nicotera P, Orrenius S. Molecular Mechanisms of Toxic Cell Death: An Overview. In Vitro Toxicity Indicators; 2013. p. 23-32. 
50. Eschenhagen T, De Angelis MH, Krönke M, Nicotera P. German centers of health research. Diabetes Stoffwechsel Herz 2012;21(4):247-249. 
51. Michod D, Bartesaghi S, Khelifi A, Bellodi C, Berliocchi L, Nicotera P, et al. Calcium-Dependent Dephosphorylation of the Histone Chaperone DAXX Regulates H3.3 Loading and Transcription upon Neuronal Activation. Neuron 2012;74(1):122-135. 
52. Nicotera P, Hampel H. Perspectives of worldwide translational biomarker research in neurodegenerative diseases. Prog Neurobiol 2011;95(4):496-497. 
53. Bano D, Zanetti F, Mende Y, Nicotera P. Neurodegenerative processes in Huntington's disease. Cell Death Dis 2011;2(11). 
54. Richards P, Didszun C, Campesan S, Simpson A, Horley B, Young KW, et al. Erratum: Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease (Cell Death and Differentiation (2011) 18 (191-200) DOI: 10.1038/cdd.2010.127). Cell Death Differ 2011;18(5):914. 
55. Ziviani E, Lippi G, Bano D, Munarriz E, Guiducci S, Zoli M, et al. Ryanodine receptor-2 upregulation and nicotine-mediated plasticity. EMBO J 2011;30(1):194-204. 
56. Lippi G, Steinert JR, Marczylo EL, D'Oro S, Fiore R, Forsythe ID, et al. Targeting of the Arpc3 actin nucleation factor by miR-29a/b regulates dendritic spine morphology. J Cell Biol 2011;194(6):889-904. 
57. Levi-Montalcini R, Knight RA, Nicotera P, Nisticó G, Bazan N, Melino G. Rita's 102!! Mol Neurobiol 2011;43(2):77-79. 
58. Bano D, Agostini M, Melino G, Nicotera P. Ageing, neuronal connectivity and brain disorders: An unsolved ripple effect. Mol Neurobiol 2011;43(2):124-130. 
59. Killick R, Niklison-Chirou M, Tomasini R, Bano D, Rufini A, Grespi F, et al. p73: A multifunctional protein in neurobiology. Mol Neurobiol 2011;43(2):139-146. 
60. Richards P, Didszun C, Campesan S, Simpson A, Horley B, Young KW, et al. Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease. Cell Death Differ 2011;18(2):191-200. 
61. Orrenius S, Nicotera P, Zhivotovsky B. Cell death mechanisms and their implications in toxicology. Toxicol Sci 2011;119(1):3-19. 
62. Leist M, Hartun T, Nicotera P. Safety Assessment of Botanicals and Botanical Preparations Used as Ingredients in Food Supplements: Testing an European Food Safety Authority-Tiered ApproachVisions on Toxicity Testing in the 21st Century: Reflections on a Strategy Document of the US National Research Council. Risk Assessment of Phytochemicals in Food: Novel Approaches; 2010. p. 38-56. 
63. Agostini M, Tucci P, Chen H, Knight RA, Bano D, Nicotera P, et al. p73 regulates maintenance of neural stem cell. Biochem Biophys Res Commun 2010;403(1):13-17. 
64. Young KW, Piñon LGP, Bampton ETW, Nicotera P. Different pathways lead to mitochondrial fragmentation during apoptotic and excitotoxic cell death in primary neurons. J Biochem Mol Toxicol 2010;24(5):335-341. 
65. Berry C, La Vecchia C, Nicotera P. Paraquat and parkinson's disease. Cell Death Differ 2010;17(7):1115-1125. 
66. Young KW, Piñón LGP, Dhiraj D, Twiddy D, MacFarlane M, Hickman J, et al. Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-xL/Bcl-w antagonist ABT-737. Neuropharmacology 2010;58(8):1258-1267. 
67. Chen H, Shalom-Feuerstein R, Riley J, Zhang S-, Tucci P, Agostini M, et al. miR-7 and miR-214 are specifically expressed during neuroblastoma differentiation, cortical development and embryonic stem cells differentiation, and control neurite outgrowth in vitro. Biochem Biophys Res Commun 2010;394(4):921-927. 
68. Bartesaghi S, Betts-Henderson J, Cain K, Dinsdale D, Zhou X, Karlsson A, et al. Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration. Hum Mol Genet 2010;19(9):1669-1677. 
69. Kroemer G, Nicotera P, Melino G. Cell death and disease: A new journal for a central area of pathophysiology. Cell Death Dis 2010;1(1). 
70. Bano D, Hengartner MO, Nicotera P. Nuclear pore complex during neuronal degeneration: Cracking the last barrier! Nucl 2010;1(2):136-138. 
71. Bano D, Dinsdale D, Cabrera-Socorro A, Maida S, Lambacher N, McColl B, et al. Alteration of the nuclear pore complex in Ca2+-mediated cell death. Cell Death Differ 2010;17(1):119-133. 
72. Smith AG, Nicotera P. Injecting the future into toxicology. Eur Pharm Rev 2009(2):28-32. 
73. Betts-Henderson J, Bartesaghi S, Crosier M, Lindsay S, Chen H-, Salomoni P, et al. The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development. Hum Mol Genet 2009;19(2):342-351. 
74. Rossi M, Munarriz ER, Bartesaghi S, Milanese M, Dinsdale D, Guerra-Martin MA, et al. Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux. J Cell Sci 2009;122(18):3330-3339. 
75. Bellodi C, Lidonnici MR, Hamilton A, Helgason GV, Soliera AR, Ronchetti M, et al. Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 2009;119(5):1109-1123. 
76. Donnini S, Solito R, Monti M, Balduini W, Carloni S, Cimino M, et al. Prevention of ischemic brain injury by treatment with the membrane penetrating apoptosis inhibitor, TAT-BH4. Cell Cycle 2009;8(8):1271-1278. 
77. Regad T, Bellodi C, Nicotera P, Salomoni P. The tumor suppressor Pml regulates cell fate in the developing neocortex. Nat Neurosci 2009;12(2):132-140. 
78. Nicotera P. Pierluigi Nicotera. Interviewed by Karen Kaplan. Nature 2009;460(7251):135. 
79. Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, et al. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ 2009;16(8):1093-1107. 
80. Di Val Cervo PR, Tucci P, Majid A, Lena AM, Agostini M, Bernardini S, et al. p73, miR106b, miR34a, and Itch in chronic lymphocytic leukemia. Blood 2009;113(25):6498-6499. 
81. Leist M, Hartung T, Nicotera P. The dawning of a new age of toxicology. ALTEX 2008;25(2):103-114. 
82. Vogler M, Dinsdale D, Sun X-, Young KW, Butterworth M, Nicotera P, et al. A novel paradigm for rapid ABT-737-induced apoptosis involving outer mitochondrial membrane rupture in primary leukemia and lymphoma cells. Cell Death Differ 2008;15(5):820-830. 
83. Hirst RA, Gosai B, Rutman A, Guerin CJ, Nicotera P, Andrew PW, et al. Streptococcus pneumoniae deficient in pneumolysin or autolysin has reduced virulence in meningitis. J Infect Dis 2008;197(5):744-751. 
84. Loh SHY, Francescut L, Lingor P, Bähr M, Nicotera P. Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen. Cell Death Differ 2008;15(2):283-298. 
85. Young KW, Bampton ETW, Pinòn L, Bano D, Nicotera P. Mitochondrial Ca2+ signalling in hippocampal neurons. Cell Calcium 2008;43(3):296-306. 
86. Melino G, Nicotera P, Macino G. In the beginning there was RNA, then came transcription regulation: The Nobel Prize Lectures 2006. Cell Death Differ 2007;14(12):1975-1976. 
87. Chernova T, Steinert JR, Guerin CJ, Nicotera P, Forsythe ID, Smith AG. Neurite degeneration induced by heme deficiency mediated via inhibition of NMDA receptor-dependent extracellular signal-regulated kinase 1/2 activation. J Neurosci 2007;27(32):8475-8485. 
88. Nicotera P, Petersen OH, Melino G, Verkhratsky A. Janus a god with two faces: Death and survival utilise same mechanisms conserved by evolution. Cell Death Differ 2007;14(7):1235-1236. 
89. Nicotera P, Melino G. Caspase-14 and epidermis maturation. Nature Cell Biol 2007;9(6):621-622. 
90. Bano D, Nicotera P. Ca2+ signals and neuronal death in brain ischemia. Stroke 2007;38(2 PART 2):674-676. 
91. Bano D, Munarriz E, Chen HL, Ziviani E, Lippi G, Young KW, et al. The plasma membrane Na+/Ca2+ exchanger is cleaved by distinct protease families in neuronal cell death. Ann New York Acad Sci 2007;1099:451-455. 
92. Zaitseva II, Sharoyko V, Størling J, Efendic S, Guerin C, Mandrup-Poulsen T, et al. RX871024 reduces NO production but does not protect against pancreatic β-cell death induced by proinflammatory cytokines. Biochem Biophys Res Commun 2006;347(4):1121-1128. 
93. Chernova T, Nicotera P, Smith AG. Heme deficiency is associated with senescence and causes suppression of N-methyl-D-aspartate receptor subunits expression in primary cortical neurons. Mol Pharmacol 2006;69(3):697-705. 
94. Berliocchi L, Bano D, Nicotera P. Ca2+ signals and death programmes in neurons. Philos Trans R Soc B Biol Sci 2005;360(1464):2255-2258. 
95. Nicotera P, Melino G. Neurodevelopment on route p63. Neuron 2005;48(5):707-709. 
96. Munarriz E, Bano D, Sayan AE, Rossi M, Melino G, Nicotera P. Calpain cleavage regulates the protein stability of p73. Biochem Biophys Res Commun 2005;333(3):954-960. 
97. Berliocchi L, Fava E, Leist M, Horvat V, Dinsdale D, Read D, et al. Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis. J Cell Biol 2005;168(4):607-618. 
98. Bano D, Young KW, Guerin CJ, LeFeuvre R, Rothwell NJ, Naldini L, et al. Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity. Cell 2005;120(2):275-285. 
99. Melino G, Knight RA, Nicotera P. How many ways to die? how many different models of cell death? Cell Death Differ 2005;12:1457-1462. 
100. Nicotera P, Melino G. Regulation of the apoptosis-necrosis switch. Oncogene 2004;23(16 REV. ISS. 2):2757-2765. 
101. Nicotera P, Bano D. The Enemy at the Gates: Ca2+ Entry through TRPM7 Channels and Anoxic Neuronal Death. Cell 2003;115(7):768-770. 
102. Chami M, Ferrari D, Nicotera P, Paterlini-Bréchot P, Rizzuto R. Caspase-dependent alterations of Ca2+ signaling in the induction of apoptosis by hepatitis B virus X protein. J Biol Chem 2003;278(34):31745-31755. 
103. Orrenius S, Zhivotovsky B, Nicotera P. Regulation of cell death: The calcium-apoptosis link. Nat Rev Mol Cell Biol 2003;4(7):552-565. 
104. Nicotera P. Molecular switches deciding the death of injured neurons. Toxicol Sci 2003;74(1):4-9. 
105. Gasic GP, Nicotera P. To die or to sleep, perhaps to dream. Toxicol Lett 2003;139(2-3):221-227. 
106. Guerin CJ, Cooper JD, Pearce DA, Nicotera P. Imaging blood-brain barrier breakdown using multi-photon confocal microscopy. Microsc Microanal 2003;9(SUPPL. 2):172-173. 
107. Nicotera P. Development and death of neurons: Sealed by a common fate? Cell Death Differ 2002;9(12):1277-1278. 
108. Lotti M, Nicotera P. A risky business. Nature 2002;416(6880):481. 
109. Nicotera P. Apoptosis and age-related disorders: Role of caspase-dependent and caspase-independent pathways. Toxicol Lett 2002;127(1-3):189-195. 
110. Steinmetz RD, Fava E, Nicotera P, Steinhilber D. A simple cell line based in vitro test system for N-methyl-D-aspartate (NMDA) receptor ligands. J Neurosci Methods 2002;113(1):99-110. 
111. Schwab BL, Guerini D, Didszun C, Bano D, Ferrando-May E, Fava E, et al. Cleavage of plasma membrane calcium pumps by caspases: A link between apoptosis and necrosis. Cell Death Differ 2002;9(8):818-831. 
112. Simon BM, Malisan F, Testi R, Nicotera P, Leist M. Disialoganglioside GD3 is released by microglia and induces oligodendrocyte apoptosis. Cell Death Differ 2002;9(7):758-767. 
113. Volbracht C, Fava E, Leist M, Nicotera P. Calpain inhibitors prevent nitric oxide-triggered excitotoxic apoptosis. Neuroreport 2001;12(17):3645-3648. 
114. Leist M, Nicotera P. Excitotoxins, nitric oxide and programmed neuronal death. Adv Cell Aging Gerontol 2001;5(C):323-347. 
115. Nicotera P. A route for prion neuroinvasion. Neuron 2001;31(3):345-348. 
116. Ferrando-May E, Cordes V, Biller-Ckovric I, Mirkovic J, Görlich D, Nicotera P. Caspases mediate nucleoporin cleavage, but not early redistribution of nuclear transport factors and modulation of nuclear permeability in apoptosis. Cell Death Differ 2001;8(5):495-505. 
117. Volbracht C, Leist M, Kolb SA, Nicotera P. Apoptosis in Caspase-inhibited Neurons. Mol Med 2001;7(1):36-48. 
118. Gerhardt E, Kügler S, Leist M, Beier C, Berliocchi L, Volbracht C, et al. Cascade of caspase activation in potassium-deprived cerebellar granule neurons: Targets for treatment with peptide and protein inhibitors of apoptosis. Mol Cell Neurosci 2001;17(4):717-731. 
119. Single B, Leist M, Nicotera P. Differential effects of Bcl-2 on cell death triggered under ATP-depleting conditions. Exp Cell Res 2001;262(1):8-16. 
120. Nucci C, Piccirilli S, Rodinò P, Nisticò R, Grandinetti M, Cerulli L, et al. Apoptosis in the dorsal lateral geniculate nucleus after monocular deprivation involves glutamate signaling, NO production, and PARP activation. Biochem Biophys Res Commun 2000;278(2):360-367. 
121. Kipp M, Schwab BL, Przybylski M, Nicotera P, Fackelmayer FO. Apoptotic cleavage of scaffold attachment factor A (SAF-A) by caspase-3 occurs at a noncanonical cleavage site. J Biol Chem 2000;275(7):5031-5036. 
122. Schulz JB, Nicotera P. Introduction: Targeted modulation of neuronal apoptosis: A double-edged sword? Brain Pathol 2000;10(2):273-275. 
123. Nicotera P, Leist M, Fava E, Berliocchi L, Volbracht C. Energy requirement for caspase activation and neuronal cell death. Brain Pathol 2000;10(2):276-282. 
124. Hansson O, Castilho RF, Kaminski Schierle GS, Karlsson J, Nicotera P, Leist M, et al. Additive effects of caspase inhibitor and lazaroid on the survival of transplanted rat and human embryonic dopamine neurons. Exp Neurol 2000;164(1):102-111. 
125. Nicotera P. Caspase requirement for neuronal apoptosis and neurodegeneration. IUBMB Life 2000;49(5):421-425. 
126. Stridh H, Fava E, Single B, Nicotera P, Orrenius S, Leist M. Tributyltin-induced apoptosis requires glycolytic adenosine trisphosphate production. Chem Res Toxicol 1999;12(10):874-882. 
127. Kühnle S, Nicotera P, Wendel A, Leist M. Prevention of endotoxin-induced lethality, but not of liver apoptosis in poly(ADP-ribose) polymerase-deficient mice. Biochem Biophys Res Commun 1999;263(2):433-438. 
128. Nicotera P, Leist M, Single B, Volbracht C. Execution of apoptosis: Converging or diverging pathways? Biol Chem 1999;380(9):1035-1040. 
129. Hansson O, Petersén Å, Leist M, Nicotera P, Castilho RF, Brundin P. Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity. Proc Natl Acad Sci U S A 1999;96(15):8727-8732. 
130. Leist M, Single B, Naumann H, Fava E, Simon B, Kühnle S, et al. Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis. Exp Cell Res 1999;249(2):396-403. 
131. Leist M, Single B, Naumann H, Fava E, Simon B, Kühnle S, et al. Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun 1999;258(1):215-221. 
132. Schierle GS, Hansson O, Leist M, Nicotera P, Widner H, Brundin P. Caspase inhibition reduces apoptosis and increases survival of nigral transplants. Nat Med 1999;5(1):97-100. 
133. Nicotera P, Leist M, Manzo L. Neuronal cell death: A demise with different shapes. Trends Pharmacol Sci 1999;20(2):46-51. 
134. Nicotera P, Lipton SA. Excitotoxins in neuronal apoptosis and necrosis. J Cereb Blood Flow Metab 1999;19(6):583-591. 
135. Carroll S, Nicotera P, Pette D. Calcium transients in single fibers of low-frequency stimulated fast- twitch muscle of rat. Am J Physiol Cell Physiol 1999;277(6 46-6):C1122-C1129. 
136. Nicotera P, Leist M, Ferrando-May E. Apoptosis and necrosis: Different execution of the same death. Biochem Soc Symp 1999;66:69-73. 
137. Schwaller B, Dick J, Dhoot G, Carroll S, Vrbova G, Nicotera P, et al. Prolonged contraction-relaxation cycle of fast-twitch muscles in parvalbumin knockout mice. Am J Physiol Cell Physiol 1999;276(2 45-2):C395-C403. 
138. Schierle GS, Leist M, Martinou J-, Widner H, Nicotera P, Brundin P. Differential effects of Bcl-2 overexpression on fibre outgrowth and survival of "embryonic dopaminergic neurons in intracerebral transplants. Eur J Neurosci 1999;11(9):3073-3081. 
139. Volbracht C, Leist M, Nicotera P. ATP controls neuronal apoptosis triggered by microtubule breakdown or potassium deprivation. Mol Med 1999;5(7):477-489. 
140. Nicotera P, Bernassola F, Melino G. Nitric oxide (NO), a signaling molecule with a killer soul. Cell Death Differ 1999;6(10):931-933. 
141. Kaminski Schierle GS, Hansson O, Ferrando-May E, Nicotera P, Brundin P, Leist M. Neuronal death in nigral grafts in the absence of poly (ADP-ribose) polymerase activation. Neuroreport 1999;10(16):3347-3351. 
142. Nicotera P, Leist M, Ferrando-May E. Intracellular ATP, a switch in the decision between apoptosis and necrosis. Toxicol Lett 1998;102-103:139-142. 
143. Pellizzari R, Rossetto O, Washbourne P, Tonello F, Nicotera PL, Montecucco C. In vitro biological activity and toxicity of tetanus and botulinum neurotoxins. Toxicol Lett 1998;102-103:191-197. 
144. Lipton SA, Nicotera P. Excitotoxicity, free radicals, necrosis, and apoptosis. Neuroscientist 1998;4(5):345-352. 
145. Leist M, Nicotera P. Apoptosis, excitotoxicity, and neuropathology. Exp Cell Res 1998;239(2):183-201. 
146. Schwab BL, Leist M, Knippers R, Nicotera P. Selective proteolysis of the nuclear replication factor MCM3 in apoptosis. Exp Cell Res 1998;238(2):415-421. 
147. Single B, Leist M, Nicotera P. Simultaneous release of adenylate kinase and cytochrome c in cell death [1]. Cell Death Differ 1998;5(12):1001-1003. 
148. Leist M, Nicotera P. Apoptosis versus necrosis: the shape of neuronal cell death. Results Probl Cell Differ 1998;24:105-135. 
149. Nicotera P, Orrenius S. The role of calcium in apoptosis. Cell Calcium 1998;23(2-3):173-180. 
150. Bachs O, Carafoli E, Nicotera P, Santella L. Preface. Cell Calcium 1998;23(2-3):77. 
151. Lipton SA, Nicotera P. Calcium, free radicals and excitotoxins in neuronal apoptosis. Cell Calcium 1998;23(2-3):165-171. 
152. Leist M, Volbracht C, Fava E, Nicotera P. 1-methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis. Mol Pharmacol 1998;54(5):789-801. 
153. Steinbach JP, Müller U, Leist M, Li Z-, Nicotera P, Aguzzi A. Hypersensitivity to seizures in β-amyloid precursor protein deficient mice. Cell Death Differ 1998;5(10):858-866. 
154. Leist M, Nicotera P. Calcium and neuronal death. Rev Physiol Biochem Pharmacol 1998;132:79-125. 
155. Rossi AD, Ahlbom E, Ögren S-, Nicotera P, Ceccatelli S. Prenatal exposure to methylmercury alters locomotor activity of male but not female rats. Exp Brain Res 1997;117(3):428-436. 
156. Göhring F, Schwab BL, Nicotera P, Leist M, Fackelmayer FO. The novel SAR-binding domain of scaffold attachment factor A (SAF-A) is a target in apoptotic nuclear breakdown. EMBO J 1997;16(24):7361-7371. 
157. Leist M, Fava E, Montecucco C, Nicotera P. Peroxynitrite and nitric oxide donors induce neuronal apoptosis by eliciting autocrine excitotoxicity. Eur J Neurosci 1997;9(7):1488-1498. 
158. Leist M, Nicotera P. The shape of cell death. Biochem Biophys Res Commun 1997;236(1):1-9. 
159. Leist M, Single B, Castoldi AF, Kühnle S, Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis. J Exp Med 1997;185(8):1481-1486. 
160. Leist M, Single B, Künstle G, Volbracht C, Hentze H, Nicotera P. Apoptosis in the absence of poly-(ADP-ribose) polymerase. Biochem Biophys Res Commun 1997;233(2):518-522. 
161. Nicotera P, Leist M. Excitotoxicity. Cell Death Differ 1997;4(6):517-518. 
162. Nicotera P, Leist M. Energy supply and the shape of death in neurons and lymphoid cells. Cell Death Differ 1997;4(6):435-442. 
163. Leist M, Volbracht C, Kühnle S, Fava E, Ferrando-May E, Nicotera P. Caspase-mediated apoptosis in neuronal excitotoxicity triggered by nitric oxide. Mol Med 1997;3(11):750-764. 
164. Carafoli E, Nicotera P, Santella L. The First European Conference on Calcium Signalling in the Cell Nucleus, Calabria, Italy, 4-8 October 1997: Report. Cell Calcium 1997;22(5):313-319. 
165. Leist M, Gantner F, Naumann H, Bluethmann H, Vogt K, Brigelius-Flohe R, et al. Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins. Gastroenterology 1997;112(3):923-934. 
166. Rossi AD, Viviani B, Zhivotovsky B, Manzo L, Orrenius S, Vahter M, et al. Inorganic mercury modifies Ca2+ signals, triggers apoptosis and potentiates NMDA toxicity in cerebellar granule neurons. Cell Death Differ 1997;4(4):317-324. 
167. Bonfoco E, Zhivotovsky B, Rossi AD, Aguilar-Santelises M, Orrenius S, Lipton SA, et al. BCL-2 delay apoptosis and PARP cleavage induced by NO donors in GT1-7 cells. Neuroreport 1997;8(1):273-276. 
168. Nicotera P, Brune B, Bagetta G. Nitric oxide: Inducer or suppressor of apoptosis? Trends Pharmacol Sci 1997;18(6):189-190. 
169. Nicotera P, Ankarcrona M, Bonfoco E, Orrenius S, Lipton SA. Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress. Adv Neurol 1997;72:95-101. 
170. Ankarcrona M, Dypbukt JM, Orrenius S, Nicotera P. Calcineurin and mitochondrial function in glutamate-induced neuronal cell death. FEBS Lett 1996;394(3):321-324. 
171. Manzo L, Artigas F, Martínez E, Mutti A, Bergamaschi E, Nicotera P, et al. Biochemical markers of neurotoxicity. A review of mechanistic studies and applications. Hum Exp Toxicol 1996;15(SUPPL. 1):S20-S35. 
172. Burkilt MJ, Milne L, Nicotera P, Orrenius S. 1,10-Phenan throline activates endogenous coppfr ions resulting in radical-mediated internucleosomal DNA fragmentation. Biochem Soc Trans 1996;24(4). 
173. Harms-Ringdahl M, Nicotera P, Radford IR. Radiation induced apoptosis. MUTAT RES REV GENET TOXICOL 1996;366(2):171-179. 
174. Viviani B, Rossi AD, Chow SC, Nicotera P. Triethyltin interferes with Ca2+ signaling and potentiates norepinephrine release in PC12 cells. Toxicol Appl Pharmacol 1996;140(2):289-295. 
175. Bonfoco E, Leist M, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P. Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation. J Neurochem 1996;67(6):2484-2493. 
176. Ankarcrona M, Zhivotovsky B, Holmström T, Diana A, Eriksson JE, Orrenius S, et al. Lamin and β-tubulin fragmentation precede chromatin degradation in glutamate-induced neuronal apoptosis. Neuroreport 1996;7(15-17):2659-2664. 
177. Orrenius S, Ankarcrona M, Nicotera P. Mechanisms of calcium-related cell death. Adv Neurol 1996;71:137-149; discussion 149-151. 
178. Nicotera P. The Gerhard Zbinden Memorial Lecture. Alteration of cell signalling in chemical toxicity. Arch Toxicol Suppl 1996;18:3-11. 
179. Burkitt MJ, Milne L, Nicotera P, Orrenius S. 1,10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat-liver nuclei by promoting the redox activity of endogenous copper ions. Biochem J 1996;313(1):163-169. 
180. Bonfoco E, Krainc D, Ankarcrona M, Nicotera P, Lipton SA. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc Natl Acad Sci U S A 1995;92(16):7162-7166. 
181. Nicotera P, Bonfoco E, Brüne B. Mechanisms for nitric oxide-induced cell death: Involvement of apoptosis. Adv Neuroimmunol 1995;5(4):411-420. 
182. Bonfoco E, Ceccatelli S, Manzo L, Nicotera P. Colchicine induces apoptosis in cerebellar granule cells. Exp Cell Res 1995;218(1):189-200. 
183. Viviani B, Rossi AD, Chow SC, Nicotera P. Organotin compounds induce calcium overload and apoptosis in PC12 cells. Neurotoxicology 1995;16(1):19-25. 
184. Zhivotovsky B, Gahm A, Ankarcrona M, Nicotera P, Orrenius S. Multiple proteases are involved in thymocyte apoptosis. Exp Cell Res 1995;221(2):404-412. 
185. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, et al. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function. Neuron 1995;15(4):961-973. 
186. Meßmer UK, Ankarcrona M, Nicotera P, Brüne B. p53 expression in nitric oxide-induced apoptosis. FEBS Lett 1994;355(1):23-26. 
187. Zhivotovsky B, Wade D, Gahm A, Orrenius S, Nicotera P. Formation of 50 kbp chromatin fragments in isolated liver nuclei is mediated by protease and endonuclease activation. FEBS Lett 1994;351(2):150-154. 
188. Zhivotovsky B, Cedervall B, Jiang S, Nicotera P, Orrenius S. Involvement of Ca2+ in the formation of high molecular weight DNA fragments in thymocyte apoptosis. Biochem Biophys Res Commun 1994;202(1):120-127. 
189. Nicotera P, Rossi AD. Nuclear Ca2+: physiological regulation and role in apoptosis. Mol Cell Biochem 1994;135(1):89-98. 
190. Nicotera P. P53 expression in nitric oxide-induced apoptosis Udo K. Meßmer a, Maria Ankarcrona b. FEBS Lett 1994;355(1):23-26. 
191. McConkey DJ, Nicotera P, Orrenius S. Signalling and Chromatin Fragmentation in Thymocyte Apoptosis. Immunol Rev 1994;142(1):343-363. 
192. Castoldi AF, Coccini T, Rossi A, Nicotera P, Costa LG, Tan XX, et al. Biomarkers in environmental medicine: Alterations of cell signalling as early indicators of neurotoxicity. Funct Neurol 1994;9(2):101-109. 
193. Jiang S, Chow SC, Nicotera P, Orrenius S. Intracellular Ca2+ signals activate apoptosis in thymocytes: Studies using the Ca2+-ATPase inhibitor thapsigargin. Exp Cell Res 1994;212(1):84-92. 
194. Ankarcrona M, Dypbukt JM, Brüne B, Nicotera P. Interleukin-1β-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells. Exp Cell Res 1994;213(1):172-177. 
195. Orrenius S, Nicotera P. The calcium ion and cell death. J Neural Transm Suppl 1994(43):1-11. 
196. Atterwill CK, Bruinink A, Drejer J, Duarte E, McFarlane Abdulla E, Meredith C, et al. In vitro neurotoxicity testing. The report and recommendations of ECVAM Workshop 3. ATLA (ALTERN LAB ANIM ) 1994;22(5):350-362. 
197. Corcoran GB, Fix L, Jones DP, Moslen MT, Nicotera P, Oberhammer FA, et al. Apoptosis: Molecular control point in toxicity. Toxicol Appl Pharmacol 1994;128(2):169-181. 
198. Dypbukt JM, Ankarcrona M, Burkitt M, Sjoholm A, Strom K, Orrenius S, et al. Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines. J Biol Chem 1994;269(48):30553-30560. 
199. Nicotera P, Zhivotovsky B, Orrenius S. Nuclear calcium transport and the role of calcium in apoptosis. Cell Calcium 1994;16(4):279-288. 
200. Zhivotovsky B, Wade D, Nicotera P, Orrenius S. Role of nucleases in apoptosis. Int Arch Allergy Immunol 1994;105(4):333-338. 
201. Nicotera P, Rossi A. Molecular mechanisms of metal neurotoxicity. J Trace Elem Electrolytes Health Dis 1993;7(4):254-256. 
202. Zhivotovsky B, Nicotera P, Bellomo G, Hanson K, Orrenius S. Ca2+ and endonuclease activation in radiation-induced lymphoid cell death. Exp Cell Res 1993;207(1):163-170. 
203. Rossi AD, Larsson O, Manzo L, Orrenius S, Vahter M, Berggren - PO, et al. Modifications of Ca2+ signaling by inorganic mercury in PC12 cells. FASEB J 1993;7(15):1507-1514. 
204. Dimmeler S, Ankarcrona M, Nicotera P, Brune B. Exogenous nitric oxide (NO) generation or IL-1β-induced intracellular NO production stimulates inhibitory auto-ADP-ribosylation of glyceraldehyde-3- phosphate dehydrogenase in RINm5F cells. J Immunol 1993;150(7):2964-2971. 
205. Juntti-Berggren L, Larsson O, Rorsman P, Ämmälä C, Bokvist K, Wåhlander K, et al. Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes. Science 1993;261(5117):86-90. 
206. Fiorentini C, Donelli G, Nicotera P, Thelestam M. Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells. Infect Immun 1993;61(9):3988-3993. 
207. Milne L, Nicotera P, Orrenius S, Burkitt MJ. Effects of Glutathione and Chelating Agents on Copper-Mediated DNA Oxidation: Pro-oxidant and Antioxidant Properties of Glutathione. Arch Biochem Biophys 1993;304(1):102-109. 
208. Dypbukt JM, Costa LG, Manzo L, Orrenius S, Nicotera P. Cytotoxic and genotoxic effects of styrene-7,8-oxide in neuroadrenergic pc 12 cells. Carcinogenesis 1992;13(3):417-424. 
209. Orrenius S, McCabe Jr. MJ, Nicotera P. Ca2+-dependent mechanisms of cytotoxicity and programmed cell death. Toxicol Lett 1992;64-65(C):357-364. 
210. MCCABE MJ, NICOTERA P, ORRENIUS S. Calcium‐Dependent Cell Death Role of the Endonuclease, Protein Kinase C, and Chromatin Conformation. Ann New York Acad Sci 1992;663(1):269-278. 
211. Nicotera P, Bellomo G, Orrenius S. Calcium-mediated mechanisms in chemically induced cell death. ANNU REV PHARMACOL TOXICOL 1992;32:449-470. 
212. Orrenius S, Burkitt MJ, Kass GEN, Dypbukt JM, Nicotera P. Calcium ions and oxidative cell injury. Ann Neurol 1992;32(1 S):S33-S42. 
213. Nicotera P, Dypbukt JM, Rossi AD, Manzo L, Orrenius S. Thiol modification and cell signalling in chemical toxicity. Toxicol Lett 1992;64-65(C):563-567. 
214. NICOTERA P, ORRENIUS S. Ca2+ and Cell Death. Ann New York Acad Sci 1992;648(1):17-27. 
215. Bellomo G, Perotti M, Taddei F, Mirabelli F, Finardi G, Nicotera P, et al. Tumor Necrosis Factor a Induces Apoptosis in Mammary Adenocarcinoma Cells by an Increase in Intranuclear Free Ca2+ Concentration and DNA Fragmentation. Cancer Res 1992;52(5):1342-1346. 
216. Fiorentini C, Donelli G, Nicotera P, Mastrantonio P, Thelestam M. On the mode of action of Clostridiumdifficile toxin A: an invitro study. Cytotechnology 1991;5(1 Supplement):84-85. 
217. Orrenius S, McConkey DJ, Nicotera P. Role of calcium in toxic and programmed cell death. ADV EXP MED BIOL 1991;283:419-425. 
218. Rossi A, Manzo L, Orrenius S, Vahter M, Nicotera P. Modifications of Cell Signalling in the Cytotoxicity of Metals. Pharmacol Toxicol 1991;68(6):424-429. 
219. Viarengo A, Nicotera P. Possible role of ca2+ in heavy metal cytotoxicity. Comparative Biochemistry and Physiology.Part C, Comparative 1991;100(1-2):81-84. 
220. Brüne B, Hartzell P, Nicotera P, Orrenius S. Spermine prevents endonuclease activation and apoptosis in thymocytes. Exp Cell Res 1991;195(2):323-329. 
221. Nicotera P, Hinds TR, Nelson SD, Vincenzi FF. Differential effects of arylating and oxidizing analogs of N-acetyl-p-benzoquinoneimine on red blood cell membrane proteins. Arch Biochem Biophys 1990;283(1):200-205. 
222. Aw TY, Nicotera P, Manzo L, Orrenius S. Tributyltin stimulates apoptosis in rat thymocytes. Arch Biochem Biophys 1990;283(1):46-50. 
223. Fransson R, Nicotera P, Wärngardi L, Ahlborg UG. Changes in cytosolic CA2+ are not involved in DDT-induced loss of gap junctional communication in WB-F344 cells. Cell Biol Toxicol 1990;6(2):235-244. 
224. Kass GE, Nicotera P, Orrenius S. Effects of xenobiotics on signal transduction and Ca2+ mediated processes in mammalian cells. Int Symp Princess Takamatsu Cancer Res Fund 1990;21:213-226. 
225. Nicotera P, Bellomo G, Orrenius S. The role of ca2+ in cell killing. Chem Res Toxicol 1990;3(6):484-494. 
226. Dypbukt JM, Thor H, Nicotera P. Intracellular ca2+ chelators prevent dna damage and protect hepatoma 1clc7 cells from quinone-induced cell killing. Free Radic Res 1990;8(4-6):347-354. 
227. Nicotera P, Orrenius S, Nilsson T, Berggren P-. An inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in liver nuclei. Proc Natl Acad Sci U S A 1990;87(17):6858-6862. 
228. McConkey DJ, Nicotera P, Hartzell P, Bellomo G, Wyllie AH, Orrenius S. Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration. Arch Biochem Biophys 1989;269(1):365-370. 
229. Remmer H, Nicotera P, Pohl L, Kupfer D, Jones D, Nerland D, et al. Symposium scenes. Drug Metab Rev 1989;20(4 --Feb):271-273. 
230. McConkey DJ, Hartzell P, Nicotera P, Orrenius S. Calcium-activated DNA fragmentation kills immature thymocytes. FASEB J 1989;3(7):1843-1849. 
231. Grafstrom RC, Edman CC, Sundqvist K, Liu Y, Hybbinette SS, Atzori L, et al. Cultured human bronchial cells as a model system in lung toxicology and carcinogenesis: Implications from studies with acrolein. ATLA, ALTERN LAB ANIM 1989;16(3):231-243. 
232. Jones DP, McConkey DJ, Nicotera P, Orrenius S. Calcium-activated DNA fragmentation in rat liver nuclei. J Biol Chem 1989;264(11):6398-6403. 
233. Nicotera P, McConkey DJ, Jones DP, Orrenius S. ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei. Proc Natl Acad Sci U S A 1989;86(2):453-457. 
234. Nicotera P, Thor H, Orrenius S. Cytosolic-free Ca2+ and cell killing in hepatoma 1c1c7 cells exposed to chemical anoxia. FASEB J 1989;3(1):59-64. 
235. Nicotera P, Rundgren M, Porubek DJ, Cotgreave I, Moldéus P, Orrenius S, et al. On the Role of Ca2+ in the Toxicity of Alkylating and Oxidizing Quinone Imines in Isolated Hepatocytes. Chem Res Toxicol 1989;2(1):46-50. 
236. Orrenius S, McConkey DJ, Bellomo G, Nicotera P. Role of Ca2+ in toxic cell killing. Trends Pharmacol Sci 1989;10(7):281-285. 
237. Nicotera P, Mc Conkey DJ, Dypbukt JM, Jones DP, Orrenius S. Ca2+ activated mechanisms in cell killing. Drug Metab Rev 1989;20(2-4):193-201. 
238. Eriksson JE, Paatero GIL, Meriluoto JAO, Codd GA, Kass GEN, Nicotera P, et al. Rapid microfilament reorganization induced in isolated rat hepatocytes by microcystin-LR, a cyclic peptide toxin. Exp Cell Res 1989;185(1):86-100. 
239. Kobayashi K, Sogame Y, Hayashi K, Nicotera P, Orrenius S. ATP stimulates the uptake of S-dinitrophenylglutathione by rat liver plasma membrane vesicles. FEBS Lett 1988;240(1-2):55-58. 
240. Nicotera P, McConkey D, Svensson S-, Bellomo G, Orrenius S. Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress. Toxicology 1988;52(1-2):55-63. 
241. Kass GEN, Wright JM, Nicotera P, Orrenius S. The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity: Role of intracellular calcium. Arch Biochem Biophys 1988;260(2):789-797. 
242. Orrenius S, McConkey DJ, Jones DP, Nicotera P. Ca2+-activated mechanisms in toxicity and programmed cell death. ISI ATLAS SCI: PHARMACOL 1988;2(4):319-324. 
243. McConkey DJ, Hartzell P, Nicotera P, Wyllie AH, Orrenius S. Stimulation of endogenous endonuclease activity in hepatocytes exposed to oxidative stress. Toxicol Lett 1988;42(2):123-130. 
244. Orrenius S, Nicotera P. Biochemical mechanisms of oxidative liver cell injury. CLIN RESPIR PHYSIOL 1987;23(4):291-295. 
245. Bellomo G, Marinoni V, Salis A, Mirabelli F, Nicotera P, Richelmi P, et al. Protective role of glutathione against oxidative stress-induced alterations in sarcoplasmic reticular calcium transport. Cardiologia 1987;32(2):199-201. 
246. Moore GA, Rossi L, Nicotera P, Orrenius S, O'Brien PJ. Quinone toxicity in hepatocytes: Studies on mitochondrial Ca2+ release induced by benzoquinone derivatives. Arch Biochem Biophys 1987;259(2):283-295. 
247. Orrenius S, Nicotera P. On the role of calcium in chemical toxicity. Arch Toxicol 1987;60(SUPPL. 11):11-19. 
248. Nicotera P, Hartzell P, Davis G, Orrenius S. The formation of plasma membrane blebs in hepatocytes exposed to agents that increase cytosolic Ca2+ is mediated by the activation of a non-lysosomal proteolytic system. FEBS Lett 1986;209(1):139-144. 
249. Nicotera P, Hartzell P, Baldi C, Svensson SA, Bellomo G, Orrenius S. Cystamine induces toxicity in hepatocytes through the elevation of cytosolic Ca2+ and the stimulation of a nonlysosomal proteolytic system. J Biol Chem 1986;261(31):14628-14635. 
250. Orrenius S, Nicotera P. Studies of Ca2+-mediated toxicity in hepatocytes. Klin Wochenschr 1986;64(SUPPL. 7):138-141. 
251. Mirabelli F, Bellomo G, Nicotera P, Moore M, Orrenius S. Ca2+ homeostasis and cytotoxicity in isolated hepatocytes: Studies with extracellular adenosine 5′‐triphosphate. J Biochem Toxicol 1986;1(1):29-39. 
252. Nicotera P, Orrenius S. Role of thiols in protection against biological reactive intermediates. Adv Exp Med Biol 1986;197:41-51. 
253. Nicotera P, Baldi C, Svensson S-, Larsson R, Bellomo G, Orrenius S. Glutathione S-conjugates stimulate ATP hydrolysis in the plasma membrane fraction of rat hepatocytes. FEBS Lett 1985;187(1):121-125. 
254. Nicotera P, Moore M, Bellomo G, Mirabelli F, Orrenius S. Demonstration and partial characterization of glutathione disulfide-stimulated ATPase activity in the plasma membrane fraction from rat hepatocytes. J Biol Chem 1985;260(4):1999-2002. 
255. Nicotera P, Moore M, Mirabelli F, Bellomo G, Orrenius S. Inhibition of hepatocyte plasma membrane Ca2+-ATPase activity by menadione metabolism and its restoration by thiols. FEBS Lett 1985;181(1):149-153. 
256. Bellomo G, Nicotera PL, Travaglino F, Martino AP, Mirabelli F, Fratino P. Insulin degradation in human erythrocyte: Effects of cations. Acta diabet lat 1985;22(1):63-69. 
257. Di Monte D, Bellomo G, Thor H, Nicotera P, Orrenius S. Menadione-induced cytotoxicity is associated with protein thiol oxidation and alteration in intracellular Ca2+ homeostasis. Arch Biochem Biophys 1984;235(2):343-350. 
258. BELLOMO G, NICOTERA P, ORRENIUS S. Alterations in intracellular calcium compartmentation following inhibition of calcium efflux from isolated hepatocytes. Eur J Biochem 1984;144(1):19-23. 
259. Bellomo G, Nicotera PL, Parini A, Fratino P. Insulin degradation-in human erythrocytes. Effect of Triton X-100 treatment on insulin-degrading activity of membranes. J Endocrinol Invest 1983;6(6):441-444. 
260. Fratino P, Bellomo G, Bellazzi R, Nicotera PL, Sandrini G, Nappi G. Insulin receptors in myotonic dystrophy: A study with mononuclear leucocytes and erythrocytes. Ital J Neuro Sci 1982;3(2):99-106. 
261. Bellomo G, Bellazzi R, Nicotera PL, Francesconi R, Fratino P. Binding and degradation of 125l-insulin in human erythrocytes. Comparative studies with hemolysate and membranes. J Endocrinol Invest 1982;5(5):287-292. 
262. Bellomo G, Nicotera PL, Fratino P. Insulin degradation in human erythrocyte. Effects of reduced glutathione on insulin degradation by hemolysate. Boll Soc Ital Biol Sper 1981;57(16):1660-1665. 
263. Bellomo G, Nicotera PL, Fratino P. Insulin degradation in human erythrocyte. Effects of reduced glutathione on insulin degradation by membrane fractions. Boll Soc Ital Biol Sper 1981;57(16):1666-1672. 
264. Fratino P, Bellomo G, Baldi C, Nicotera PL. Effects of phenformin on insulin binding to monocytes and erythrocytes. Diabetologia 1981;21(3):164.